bcg mycobacterial strain Search Results


bcg mycobacterial strain  (David Sherman)
90
David Sherman bcg mycobacterial strain
ESAT-6 induces Th2 cell differentiation via IL-1β production. A , IL-4 production in DCs co-cultured with naïve OT-II CD4 + T cells after infection with H37Rv or <t>BCG</t> in the presence or absence of anti-IL-1β. B , IL-4 production in DCs co-cultured with naïve OT-II CD4 + T cells after infection with H37Rv or mutant strains <t>(H37RvΔRD1,</t> <t>H37RvΔESAT-6,</t> and Comp ESAT-6) in the presence or absence of anti-IL-1β. IL-4 levels were higher in cultures with H37Rv or Comp ESAT-6 compared with cultures with BCG or other mutant strains ( p < 0.003). C , Western blot analysis of STAT6, pSTAT6, STAT4, and pSTAT4 proteins from DCs infected with H37Rv or H37RvΔESAT-6 and co-cultured with OT-II CD4 + T cells, to show modulated Th1 and Th2 responses in the presence or absence of anti-IL-1β. The results shown are representative of at least four independent experiments. Error bars , ±S.D.
Bcg Mycobacterial Strain, supplied by David Sherman, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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bcg mycobacterial strain - by Bioz Stars, 2026-09
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ESAT-6 induces Th2 cell differentiation via IL-1β production. A , IL-4 production in DCs co-cultured with naïve OT-II CD4 + T cells after infection with H37Rv or BCG in the presence or absence of anti-IL-1β. B , IL-4 production in DCs co-cultured with naïve OT-II CD4 + T cells after infection with H37Rv or mutant strains (H37RvΔRD1, H37RvΔESAT-6, and Comp ESAT-6) in the presence or absence of anti-IL-1β. IL-4 levels were higher in cultures with H37Rv or Comp ESAT-6 compared with cultures with BCG or other mutant strains ( p < 0.003). C , Western blot analysis of STAT6, pSTAT6, STAT4, and pSTAT4 proteins from DCs infected with H37Rv or H37RvΔESAT-6 and co-cultured with OT-II CD4 + T cells, to show modulated Th1 and Th2 responses in the presence or absence of anti-IL-1β. The results shown are representative of at least four independent experiments. Error bars , ±S.D.

Journal: The Journal of Biological Chemistry

Article Title: Mycobacterium tuberculosis Directs T Helper 2 Cell Differentiation by Inducing Interleukin-1β Production in Dendritic Cells

doi: 10.1074/jbc.M112.375154

Figure Lengend Snippet: ESAT-6 induces Th2 cell differentiation via IL-1β production. A , IL-4 production in DCs co-cultured with naïve OT-II CD4 + T cells after infection with H37Rv or BCG in the presence or absence of anti-IL-1β. B , IL-4 production in DCs co-cultured with naïve OT-II CD4 + T cells after infection with H37Rv or mutant strains (H37RvΔRD1, H37RvΔESAT-6, and Comp ESAT-6) in the presence or absence of anti-IL-1β. IL-4 levels were higher in cultures with H37Rv or Comp ESAT-6 compared with cultures with BCG or other mutant strains ( p < 0.003). C , Western blot analysis of STAT6, pSTAT6, STAT4, and pSTAT4 proteins from DCs infected with H37Rv or H37RvΔESAT-6 and co-cultured with OT-II CD4 + T cells, to show modulated Th1 and Th2 responses in the presence or absence of anti-IL-1β. The results shown are representative of at least four independent experiments. Error bars , ±S.D.

Article Snippet: BCG, H37RvΔRD-1, H37RvΔESAT-6, and ESAT-6-complemented H37RvΔESAT-6 were a kind gift from Prof. David Sherman (SBRI, Seattle, WA).

Techniques: Cell Differentiation, Cell Culture, Infection, Mutagenesis, Western Blot

H37Rv induces significantly higher Th2 responses and the proinflammatory cytokine IL-1β compared with BCG or H37RvΔESAT-6. A , cytokine levels in lung homogenates of mice at different time points after infection with H37Rv or BCG. B , cytokine levels in lung homogenates of mice at different time points after infection with H37Rv or mutant strain H37RvΔESAT-6. Statistical significance between different strains was determined by one-way ANOVA: *, p < 0.01; **, p < 0.017; ***, p < 0.001. The results shown are representative of at least three independent experiments with six mice within each group. Error bars , ±S.D.

Journal: The Journal of Biological Chemistry

Article Title: Mycobacterium tuberculosis Directs T Helper 2 Cell Differentiation by Inducing Interleukin-1β Production in Dendritic Cells

doi: 10.1074/jbc.M112.375154

Figure Lengend Snippet: H37Rv induces significantly higher Th2 responses and the proinflammatory cytokine IL-1β compared with BCG or H37RvΔESAT-6. A , cytokine levels in lung homogenates of mice at different time points after infection with H37Rv or BCG. B , cytokine levels in lung homogenates of mice at different time points after infection with H37Rv or mutant strain H37RvΔESAT-6. Statistical significance between different strains was determined by one-way ANOVA: *, p < 0.01; **, p < 0.017; ***, p < 0.001. The results shown are representative of at least three independent experiments with six mice within each group. Error bars , ±S.D.

Article Snippet: BCG, H37RvΔRD-1, H37RvΔESAT-6, and ESAT-6-complemented H37RvΔESAT-6 were a kind gift from Prof. David Sherman (SBRI, Seattle, WA).

Techniques: Infection, Mutagenesis